Ligands for E3 Ligase Inhibitors

von Hippel-Lindau (VHL)

MDM2

Cereblon

IAP

KLHDC2

Fbxo3

RNF4

DCAF11

DCAF1

UHRF1

TRIM21

Ligands for E3 Ligase Degraders, Controls, Ligands, Inhibitors, Modulators & Chemicals

Product Name	von Hippel-Lindau (VHL)	MDM2	Cereblon	IAP	KLHDC2	Fbxo3	RNF4	DCAF11	DCAF1	UHRF1	TRIM21	Purity
Pomalidomide			Cereblon									99.96%
Lenalidomide			Cereblon									99.95%
CC-885			Cereblon Cereblon									99.85%
Eragidomide			Cereblon									99.86%
CRBN ligand-109			Cereblon									99.11%
Iberdomide			Cereblon Cereblon									99.54%
PT-179			Cereblon Cereblon									99.91%
VH-298	VHL											99.78%
VH032	VHL											99.64%
(S,R,S)-AHPC-Me hydrochloride	VHL											99.95%
(S,R,S)-AHPC	VHL											99.13%
Golcadomide			Cereblon									98.04%
(S,R,S)-AHPC monohydrochloride	VHL											99.83%
E3 ligase Ligand 32	VHL											99.95%
(S,R,S)-AHPC-Me	VHL											99.96%
Lenalidomide hemihydrate			Cereblon									99.98%
ALV2			Cereblon Cereblon									98.07%
BC-1215						Fbxo3						99.94%
Lenalidomide-Br			Cereblon									99.86%
ALV1			Cereblon									98.62%
NCT02			Cereblon-DDB1									98.14%
BMS-986397			Cereblon									99.76%
VHL-IN-1	VHL											99.84%
(S,S,S)-AHPC hydrochloride	VHL											99.16%
BODIPY FL thalidomide			Cereblon, Kd: 3.6 nM									99.18%
VH032-cyclopropane-F	VHL											99.92%
VH 101, acid	VHL											98.82%
(S)-Thalidomide			Cereblon									99.52%
NV03										UHRF1		99.77%
Lenalidomide-I			Cereblon Cereblon									99.90%
CCW16							RNF4					98.73%
CC-3060			Cereblon Cereblon									99.7%
Nutlin carboxylic acid		MDM2										98.63%
cIAP1 ligand 1				cIAP1								99.90%
DCAF1 binder 1			Cereblon Cereblon									99.12%
(S,R,S)-AHPC-propargyl	VHL											99.46%
N-Me-Thalidomide 4-fluoride			Cereblon Cereblon									99.41%
Lenalidomide-OH			Cereblon									99.48%
VHL Ligand 8	VHL											98.04%
VL285	VHL											99.34%
Thalidomide (Standard)			Cereblon Cereblon
(S,R,S)-AHPC-Boc	VHL
KB02-COOH			Cereblon									99.39%
(S,R,S)-AHPC-Me dihydrochloride	VHL											99.84%
VHL Ligand 14	VHL											99.93%
OICR-8268			Cereblon Cereblon									99.23%
PD 4'-oxyacetic acid			Cereblon Cereblon									99.69%
CRBN ligand-13			Cereblon
TD-106			Cereblon Cereblon									99.81%
(R,S,S)-VH032	VHL											98.99%
CC-17369			Cereblon									98.68%
Pomalidomide-5-OH			Cereblon									99.46%
2-Methoxyphenyl dihydrouracil			Cereblon
Lenalidomide (Standard)			Cereblon Cereblon
Lenalidomide 5'-piperazine-4-methylpiperidine hydrochloride			Cereblon Cereblon
Lenalidomide 5'-piperazine			Cereblon Cereblon									99.92%
AR antagonist 1 hydrochloride	VHL											99.53%
CRBN modulator-1			Cereblon									98.00%
3-(4-Bromo-2-chlorophenyl)piperidine-2,6-dione			Cereblon									98.92%
VH 101, thiol	VHL											98.66%
Thalidomide-piperazine hydrochloride			Cereblon									98.27%
CRBN ligand-9			Cereblon Cereblon									≥98.0%
GNE7599	VHL
E3 ligase Ligand 23			Cereblon									99.71%
Pomalidomide-d₃			Cereblon Cereblon									≥99.0%
Thalidomide-pyrrolidine hydrochloride			Cereblon Cereblon									≥98.0%
cis VH-298	VHL
Lenalidomide-F			Cereblon									99.89%
Cereblon inhibitor 2			Cereblon Cereblon									98.86%
Thalidomide-d₄			Cereblon									98.00%
VL285 Phenol	VHL											98.56%
Lenalidomide-d₅			Cereblon Cereblon									99.32%
Pomalidomide-6-OH			Cereblon									98.09%
E3 ligase Ligand 18			Cereblon									99.22%
SJF-0661	VHL
Cereblon inhibitor 1			Cereblon									99.19%
Thalidomide-5-methyl			Cereblon									99.87%
E3 ligase Ligand PG			Cereblon, IC₅₀: 2.191 μM									99.94%
E3 ligase Ligand 8				IAP IAP								99.32%
VH032 thiol	VHL
Pomalidomide 5'-piperazine-4-methylpiperidine dihydrochloride			Cereblon Cereblon									98.08%
(R)-Thalidomide			Cereblon									99.80%
Lenalidomide hydrochloride			Cereblon
Pomalidomide-d₄			Cereblon Cereblon
Pomalidomide-piperazine			Cereblon Cereblon
E3 ligase Ligand 7								DCAF11
Acepromazine-OTs											TRIM21
DA-PROTAC	VHL
VH032-CH2-Boc	VHL
E3 ligase Ligand 42			Cereblon
E3 ligase Ligand 33	VHL
E3 ligase Ligand 22			Cereblon
E3 ligase Ligand 45	VHL
E3 ligase Ligand 36	VHL
OICR-8268-acrylic acid	VHL
AS1411-C4-VH032		MDM2
E3 ligase Ligand 14				IAP IAP
E3 ligase Ligand 35	VHL
Pomalidomide-6-O-CH3			Cereblon
(R)-Pomalidomide-pyrrolidine			Cereblon Cereblon
E3 ligase Ligand 48			Cereblon
E3 ligase Ligand 37	VHL
(4R,5S)-Nutlin carboxylic acid		MDM2
(S)-Deoxy-thalidomide			Cereblon Cereblon
(S)-Deoxy-thalidomide-Br			Cereblon
Lenalidomide-¹³C₅,¹⁵N			Cereblon Cereblon
SJ46411-Br	VHL
HOXB7 8–25		MDM2
E3 ligase Ligand 25			Cereblon
E3 ligase Ligand 10				IAP IAP
E3 ligase Ligand 27	VHL
(S,R,R)-VH032	VHL
PROTAC CRBN ligand-2			Cereblon
Me-SJ46411	VHL
cIAP1 ligand 4				IAP IAP
Pomalidomide 5'-fluoro-6'-piperazine-4-methylpiperidine hydrochloride			Cereblon Cereblon
(S,R,S)-AHPC-Ala	VHL
E3 ligase Ligand 41			Cereblon
VH032 analogue-2	VHL
VH032-NH-CO-CH2-NHBoc	VHL
E3 ligase Ligand 43	VHL
(S,R,S)-AHPC-O-CF3	VHL
Thalidomide-azetidine-CHO			Cereblon Cereblon
cIAP1 ligand 2				cIAP1
(S,R,S)-AHPC dihydrochloride	VHL
E3 ligase Ligand 38			Cereblon
L321			Cereblon
Pomalidomide-¹⁵N,¹³C₅			Cereblon Cereblon
E3 ligase Ligand 57			Cereblon
(S,R,S,R)-AHPC-Me	VHL
Thalidomide-(2)piperidine			Cereblon Cereblon
BCL-xL/BCL-2 ligand 1	VHL
CRBN ligand-1			Cereblon Cereblon
Ru-Poma			Cereblon Cereblon
E3 ligase Ligand 31			Cereblon
N-Boc-SBP-0636457-OH				cIAP1
E3 ligase Ligand 44	VHL
MY-11B									DCAF1
RR-11055			Cereblon Cereblon
Pomalidomide-d₅			Cereblon Cereblon
E3 ligase Ligand 26			Cereblon
Aster-A Ligand-3			Cereblon
E3 ligase Ligand 34	VHL
MEL23		MDM2
HL389			Cereblon
E3 ubiquitin ligase binder-1			Cereblon Cereblon
VH032 analogue-1	VHL
SOS1 Ligand intermediate-2	VHL
tDHU, acid			Cereblon Cereblon									98.83%
E3 ligase Ligand 13				IAP IAP
VHL-SF2	VHL
E3 ligase Ligand 29	VHL
Cyclopropane-(S,R,S)-AHPC	VHL
Thalidomide-methylpyrrolidine			Cereblon Cereblon
E3 ligase Ligand 21			Cereblon
(3S)Lenalidomide-5-Br			Cereblon
(S,R,S)-AHPC-Ac	VHL
Pomalidomide-5-O-CH3			Cereblon
CRBN ligand-162			Cereblon
AR antagonist 1	VHL
BWA-522 intermediate-1			Cereblon Cereblon									99.27%
CRBN ligand-164			Cereblon
N-Methylated pomalidomide			Cereblon
CRBN ligand-16			Cereblon
CRBN ligand-84			Cereblon
3-(4-Bromo-2-fluorophenyl)piperidine-2,6-dione			Cereblon									98.55%
CRBN ligand-45			Cereblon
CRBN ligand-63			Cereblon
CRBN ligand-111			Cereblon
Thalidomide-NH-CH2-COOH TFA			Cereblon
CRBN ligand-17			Cereblon
Benzothiazole-CH2(NH-CO-CH2Cl)-CONH-CH2-Ph	VHL
CRBN ligand-148			Cereblon
SOS1 Ligand intermediate-1	VHL
CRBN ligand-76			Cereblon
CRBN ligand-108			Cereblon
CRBN ligand-112			Cereblon
Pomalidomide (Standard)			Cereblon Cereblon
CRBN ligand-14			Cereblon
CRBN ligand-110			Cereblon
(S,R,S)-AHPC(Me)-amido-C2-acid	VHL
CRBN ligand-83			Cereblon
Thalidomide-5-piperazine			Cereblon Cereblon
CRBN ligand-74			Cereblon
Phenyl-glutarimide 4'-oxyacetic acid			Cereblon Cereblon
3-(5-Bromo-2-chlorophenyl)piperidine-2,6-dione			Cereblon
SJ6145					KLHDC2
CRBN ligand-181			Cereblon
CRBN ligand-183			Cereblon
E3 ligase Ligand 30	VHL
CRBN ligand-47			Cereblon
(S,R,S)-AHPC TFA	VHL
Bestatin-amido-Me				cIAP1
MV-1-NH-Me				cIAP1

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